Research output per year
Research output per year
Personal profile
About
Todd J. Sullivan, Ph.D. is a lecturer in the Chemistry Department at Sacred Heart University.
Currently in our research group we are performing traditional medicinal chemistry techniques to discover compounds that are biologically active against different enzymes. We are studying two different enzymes one that is involved in diabetes (Insulin Degrading Enzyme), the other that is in cancer cells (Arginase). Employing molecular modeling software programs we have generated models to produce molecular docking data. Molecular docking studies reveal how tight the virtual compounds are binding at the active site and along with structural, kinetic data we are searching for a pharmacological hit.
We are also looking for biological clues to guide our studies of inhibition of these enzymes. Eventually after optimizing our pharmaceutical hit with different virtual compounds we will use synthetic organic chemistry, molecular modeling, and structure activity relationships to advance the projects into lead and drug space with acceptable pharmacokinetic properties. Another facet to drug discovery fragment based drug design will be employed to discover novel inhibitors.
Contact Information
Chemistry
Science Ctr of Academic Bldg SC*105I
203-371-7974
Related documents
Education/Academic qualification
Post-doctoral, Yale University
… → 2006
Ph.D. Organic-Medicinal Chemistry, State University of New York at Stony Brook
… → 2005
M.S. Organic-Medicinal Chemistry, State University of New York at Stony Brook
… → 2005
B.S. Chemistry, University of Connecticut
… → 1997
Research Interests
- Pharmaceutical drug design
- Medicinal chemistry
Disciplines
- Biochemistry
- Chemistry
- Medicinal-Pharmaceutical Chemistry
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Integrated Screening for Beta-Lactamases Inhibitors Identification of Pharmaceutical Hits and Lead Optimization
Sullivan, T. J., Kafel, H. W., Bedel-Franklin, K., Burt, C. A., Bayer, E. J., De Souza, L., Peredy, T., Voulo, M. A., Galasinski, Z., Fleischmann, D., Ingegneri, K., Alper, B. & Audie, J., Apr 24 2020.Research output: Contribution to conference › Poster › peer-review
Open AccessFile -
Computational Design of Novel Insulin Degrading Enzyme Inhibitors
Sullivan, T. J., Bondela, S. S., Tamma, N., Cingolani, B., O’Neill, A., Finelli, A., Alper, B. & Audie, J., Apr 20 2018.Research output: Contribution to conference › Presentation
Open AccessFile -
Integrated Screening for Arginase Inhibitors
Sullivan, T. J., Bondela, S. S., Russo, R., Jones, E., Albilady, H., Alper, B. & Audie, J., Apr 20 2018.Research output: Contribution to conference › Presentation
Open AccessFile -
Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase.
Sharma, H., Landau, M. J., Sullivan, T. J., Kumar, V. P., Dahlgren, M. K., Jorgensen, W. L. & Anderson, K. S., Jan 2 2014, In: Bioorganic & Medicinal Chemistry Letters. 24Research output: Contribution to journal › Article › peer-review
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Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy.
Bailey, C. M., Sullivan, T. J., Iyidogan, P., Tirado-Rives, J., Chung, R., Ruiz-Caro, J., Mohamed, E., Jorgensen, W. L., Hunter, R. & Anderson, K. S., May 23 2013, In: Journal of Medicinal Chemistry. 56Research output: Contribution to journal › Article › peer-review
Press/Media
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Texas State names new directors and department chairs for 2022/2023 school year
8/31/22
1 item of Media coverage
Press/Media: Research